Available Positions

The Hannafon Laboratory at the University of Oklahoma Health Sciences is seeking a postdoctoral fellow to study chemoresistance and develop therapeutic approaches, including monoclonal antibody and immunotherapeutic approaches.  The successful candidate should be a highly ambitious and self-motivated scientist with good organization skills, and excellent written and verbal communication skills. 

The research focus of the Hannafon laboratory is to discover and investigate the cellular and molecular mechanisms of breast and gynecologic cancer development and progression, to ascertain the role of the tumor microenvironment including immune-mediated mechanisms, and to discover novel treatment strategies to overcome therapeutic resistance and improve patient outcomes.  Our recent efforts have focused on evaluating the role of doublecortin-like-kinase 1 (DCLK1) in promoting platinum resistance and cancer-stem-cell phenotypes in ovarian cancer. In this space, we are currently developing new small molecule, humanized monoclonal antibodies, and cell-based immunotherapies to overcome chemotherapy and PARP inhibitor resistance in ovarian cancers with the ultimate goal of improving patient survival and outcomes. This work is currently funded by the Department of Defense, the Ovarian Cancer Research Alliance, and the Foundation for Women’s Cancer.

Interested candidates should send a CV, a brief one-paragraph description of previous research experience, and a list of 3 references to Bethany-hannafon@ouhsc.edu

Requirements:

Teamwork: Being a good laboratory team member and working collaboratively with others.

Cell culture. Maintain cell cultures and reagents, and cell line inventories. Conduct experiments to analyze the effects of treatments using various cell based and biochemical assays. 

Animal Testing. Must Perform specialized tests on experimental animals including tumor cell injection, weighing, administration of drugs, maintaining a census, and surgeries in mice models. 

Molecular, Cellular, and Biochemical Analysis. Perform a variety of assays on cells, and human or animal tissues, including DNA/RNA/protein extraction, PCR, growth assays, immunoblotting, and other specific routine assays, as required. 

Data Collection and Maintenance.  Enter, compile and graph data, maintain a laboratory notebook, maintain spreadsheets and data files, and analyze data, including biostatistical analyses.

Equipment Maintenance.  Maintain laboratory space, laboratory supplies, and equipment, assesses lab group needs to order and stock supplies and equipment. 

And as Needed.  Perform various duties as needed to successfully fulfill the function of the position.

Duties:

The candidate will be expected to perform research, write manuscripts, and present findings at local and national meetings. The candidate will also assist in writing grant proposals and will be highly encouraged to submit fellowship applications (both intramural and extramural).

Preferred:

• Previous experience in cancer biology laboratory and animal handling and willingness to work with mice.

Application:

Please submit the following documents to Bethany-hannafon@ouhsc.edu

• CV
• One paragraph description of previous research experience
• List of 3 professional references.

Postdoctoral Training Position in Developmental Vascular Biology at the University of Oklahoma Health Sciences

Position Overview: The Developmental Vascular Biology Group is part of the Center for Pregnancy and Newborn Health, in the Department of Pediatrics at the University of Oklahoma Health Sciences. We are seeking a highly motivated post-doctoral fellow eager to contribute to groundbreaking research in vascular biology, immunology, and visual diseases in newborn infants.  Our lab is well-funded through NIH and institutional support, providing a robust platform for innovative scientific discovery. Dr. Faizah Bhatti is an MD clinician-scientist and senior PI in the group. She also holds appointments in the Departments of Ophthalmology, the Neuroscience program and is a member of the Oklahoma City Angiogenesis Group. She is a national leader serving on the executive boards of several research organizations and has mentored over 30 undergraduate, graduate, residents, fellows, and junior faculty. 

Research Focus: The focus of our research program is to better understand how inflammation increases the risk of abnormal blood vessel development in prematurely born infants and ultimately find ways to prevent complications related to vascular dysgenesis. Retinopathy of prematurity (ROP) can lead to varying degrees of lifelong visual impairment and blindness in preterm infants. Our primary objective is to leverage basic, translational, and clinical research approaches to address and mitigate the vascular developmental abnormalities observed in retinal disease, premature lung conditions, and hemorrhagic or ischemic brain disorders. The Developmental Vascular Biology Group is housed in a state-of-the-art 860 sq foot laboratory supported by OUHSC central imaging, histology, genomics and data science cores.  We actively participate in clinical trials involving therapeutics and clinical aspects of ROP in the neonatal subjects at the OUHSC Children’s Hospital of Oklahoma. To date, our program has secured over $5.5 Million in research funding from various sources, including the National Institute of Health/National Eye Institute, industry partners, and private foundations.

We discovered that the immunomodulatory surfactant protein a (SP-A) is expressed in the retina and defined the pro-angiogenic neovascular phenotype of SP-A in a mouse ROP model as well as in preterm infants, but the molecular mechanisms are not currently known. We utilize a multi-pronged approach to interrogate vascular and endothelial cell signaling pathways:

1. We utilize rodent models to study retinal vascular disease phenotypes and molecular targets. This is further supported by a variety of cell culture models to investigate candidate cells, including retinal endothelial cells, perivascular cells, immune cells, and the extracellular matrix. These models also explore the complex interactions within this niche, focusing on the connections between immunomodulatory pathways, redox perturbations, and other stressors.
2. Our translational approach involves analyzing clinical data and assessing biological tissues and hemodynamic variables to identify the most informative inflammatory and physiological parameters. This helps in early detection and understanding risk factors associated with retinal vascular disease.
3. We also participate in a range of clinical trials focused on evaluating critical therapeutic approaches for infants, aimed at preventing and treating ROP and other vascular diseases.

The Center for Pregnancy and Newborn Health: The Bhatti lab operates within the Developmental Vascular Biology Group under the umbrella of the Center for Pregnancy and Newborn Health. We are a multi-investigator group of clinicians and basic scientists invested in improving outcomes for children born with diseases that impact immediate and long-term outcomes and quality of life. We focus on three programmatic areas: a) Developmental Vascular Biology, b) Necrotizing Enterocolitis and Nutrition, and c) Cardiopulmonary Disease. Predoctoral students and postdoctoral graduate and clinical fellows in the department consistently secure competitive individual funding from organizations such as the National Institutes of Health, and American Heart Association.  

Responsibilities: The postdoctoral fellow will be expected to work within the Bhatti lab’s research scope related to vascular biology, immunology, and endothelial cell biology. Individuals will:

1. plan, design and conduct research experiments.
2. manage research projects.
3. prepare reports and papers for publication, presentation and future research.
4. contribute to grant writing and are encouraged to write applications for fellowships.
5. learn the complexities of research lab management and
6. participate in various lab activities and responsibilities as assigned.

They will be expected to work collaboratively and collegially as part of the team while developing skills needed to develop into an independent scientist. Our program is dedicated to the support of independent scientific career trajectories which is highly encouraged.

Qualifications:

1. Ph.D. or MD/Ph.D. in a relevant field.
2. Extensive experience in molecular biology, cell biology, and transgenic mouse models is required, with a preference for expertise in endothelial cell biology.
3. Work in retinal biology is preferable but not mandatory.
4. Demonstrates strong motivation and self-discipline, combined with the ability to work effectively in a collaborative team environment.

Salary: Commensurate with experience and guided by NIH Post-doctoral Salary Guidelines as follows.

More information about institutional support for post-doctoral trainees and policies can be found here: https://graduate.ouhsc.edu/Postdoctoral-Fellows

Application Process: Interested candidates should send their CV along with a brief research statement and contact information for three referees to faizah-bhatti@ouhsc.edu.

Posted 9/17/2024

Laboratory of Elizabeth Hile

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The Cancer Rehabilitation Research Laboratory (CRRL) in the NCI-accredited Stephenson Cancer Center at the University of Oklahoma (OU) has an immediate opening for a Postdoctoral Research Fellow at an annual salary of $63,000 for up to 2 years.  The CRRL aims to optimize early detection and intervention for cancer-related neuromuscular toxicities impacting survivors’ movement and Quality of Life. Toward this aim, we collaborate with OU Norman engineers on related biotechnologies and artificial intelligence algorithms, and with OU Health clinics to recruit individuals with cancers, especially gynecologic, hematologic, hepatobiliary, and bladder.

Expectations: The postdoctoral fellow will expand their skills toward independently conducting, disseminating, and leading research.  They will accomplish these objectives through self-directed, active learning as they perform activities that include, but are not limited to: 

• All daily research tasks required for active CRRL study protocols, including recruitment and eligibility screening of participants, the collection and management of human performance data and patient-reported outcomes, and the provision of study interventions.  
• Preparation of developing study protocols and regulatory submissions for institutional research approvals. The fellow will also assist the PI in preparing intramural and extramural funding applications.
• Analysis of existing laboratory data for publication and national presentation.  Authorship is earned, in an order commensurate with the level of independent contributions. 
• Co-mentoring of laboratory trainees, including undergraduate and graduate students.  Didactic teaching opportunities (e.g., guest lectures) may also be available through the OU College of Allied Health.

Active attendance at research meetings is required, and the fellow must present their progress weekly. The submission of at least one first-authored manuscript and national abstract are expected in the first year of training.  Funding for a second year of training will be contingent upon satisfactory performance evaluations in Year 1.

Eligibility:  Requirements include the completion of a dissertation-based doctoral degree (PhD preferred), experience in the conduct and analysis of human participants’ research in an area related to rehabilitation, and a history of research dissemination in the form of presentations and publications.  A history of clinical practice is preferred; physical therapists eligible for licensure in the State of Oklahoma will receive the highest priority.   The applicant must have strong written and verbal English-language communication skills, the ability to safely engage with study participants of diverse ages, cultural backgrounds, and physical function, and confidence to learn human performance technology.  Statistical assistance is available; however, we seek a motivated problem-solver with strong analytical and reasoning skills to clean, visualize, and interpret human performance data with minimal supervision from the PI. 

To Apply:  Send a cover letter (2-page maximum) detailing relevant research experience and interests, a curriculum vitae, and two letters of reference to Dr. Elizabeth Hile (Elizabeth-Hile@ouhsc.edu).

About Oklahoma City:  OKC is the anchor of a rapidly growing, multicultural metropolitan area with a population of 1.3 million, over 300 days of sunshine annually, very affordable cost of living, excellent schools, and a wide array of cultural amenities. https://www.youtube.com/watch?v=N-0cPNJPRLY; http://bricktownokc.com/  The University of Oklahoma is an EO/AA Institution http://www.ou.edu/eoo/ .

Posted 7/30/2024 

A postdoctoral research fellow position is available immediately in the Department of Biochemistry and Physiology and the Center for Geroscience and Healthy Brain Aging at the University of Oklahoma Health Sciences. The applicant will work on metabolic disturbances underlying brain aging and Alzheimer’s disease (AD) using rodent models, with a specific focus on the role of astrocyte mitochondrial function and reactive astrogliosis.

The successful candidate should hold a Ph.D. in neuroscience, biochemistry, genetics, cellular or molecular biology, physiology, or other related fields and have a record of creativity and strong scientific productivity. Working experience on mouse models, assessment of mitochondrial function (O2K, Seahorse), confocal imaging, primary neuron/astrocyte cell culture, molecular biology and mouse genetics, and a background in neuroscience are strongly preferred, but not exclusively required. Please provide a curriculum vitae, a brief summary of research experience and goals, and the names and contact information of three references to Dr. Sreemathi Logan (Sreemathi-Logan@ouhsc.edu).

Posted 6/24/2024

UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER RESEARCH FELLOWSHIP

The TSET Health Promotion Research Center (TSET) located within the Stephenson Cancer Center at the University of Oklahoma Health Sciences Center is recruiting a postdoctoral research fellowship interested in obtaining specialized research experience in tobacco regulatory science and health disparities fellow research. Part of the position will be supported by a newly funded Center on Health Equity Research (CHERC) from the American Cancer Society. Working with Amy M. Cohn, PhD (amy-cohn@ouhsc.edu) and Laura Beebe, PhD (laura-beebe@ouhsc.edu), the fellow will be involved in manuscript writing (primary and secondary) and analyses using data from multiple completed and ongoing projects that address menthol cigarette smoking in vulnerable populations, cannabis and tobacco use and co-use, and laboratory and behavioral economic assessments of flavored tobacco product use and appeal. Drs. Cohn and Beebe have access to several large national and statewide data sets including all the restricted use datasets of the Population Assessment of Tobacco and Health (PATH) study (and associated biomarker datasets), the National Youth Tobacco Survey, and registration and follow-up data from the Oklahoma Tobacco Helpline, which is consistently ranked as a top performing quitline in the US for enrollments (~20k/year) and outcomes. The fellow will receive training in advanced statistical analyses, such as multi-level modeling and latent trajectory and latent transition analysis, grant writing, clinical trials management, ecological momentary assessment, and human laboratory studies of tobacco use. The fellowship is expected to be 2-3 years long and benefits include a generous stipend for research activities, professional development, and travel funds. Salary is extremely competitive ($67k annual). Dr. Cohn, the HPRC faculty, and the HPRC training program has an exceptional track record of helping fellows secure tenure-track positions and establish themselves as independent investigators and receiving grants. Please contact Dr. Cohn with questions about these positions.

Eligibility: Applicants must have a doctoral degree in public health, psychology, or a related behavioral science discipline. The fellow will be selected on the basis of scholarly activity (publications, conference presentations), productivity, and commitment to a research career. Outstanding candidates must be highly motivated, possess strong analytic skills, be able to work independently, and have a strong desire to learn and expand their interests and expertise.

To apply: Send a cover letter, curriculum vitae, statement of research interests, and three letters of reference to Dr. Cohn (amy-cohn@ouhsc.edu). Applications will be reviewed as they are received.
About us: The mission of the TSET Health Promotion Research Center (HPRC) is to reduce the burden of disease in Oklahoma by addressing modifiable health risk factors such as tobacco use, sedentary lifestyle, poor diet, cancer screening, and risky alcohol and other substance use through research, novel intervention development, and dissemination of research findings. The HPRC contains four major resources that facilitate research and are led by HPRC faculty: Mobile Health Shared Resource, Tobacco Treatment Research Program, Training Program, and Tobacco Regulatory Science Clinical Laboratory. Oklahoma City is the anchor of a rapidly growing, multicultural metropolitan area with a population of 1.3 million, over 300 days of sunshine annually, very affordable cost of living, excellent schools, and a wide array of cultural amenities. Be a part of a city on the rise: Oklahoma City. https://www.youtube.com/watch?v=N-0cPNJPRLY; http://bricktownokc.com/ The University of Oklahoma is an EO/AA Institution http://www.ou.edu/eoo/.

Posted 6/14/2024

A postdoctoral research fellow position is available in the Department of Pharmaceutical Sciences at the University of Oklahoma Health Sciences Center, Oklahoma City. Dr. Joshi’s laboratory is seeking a highly motivated and proactive postdoctoral fellow to study role of nuclear receptor signaling in hepatic diseases. The successful candidate will utilize contemporary molecular, biochemical, and pharmacological approaches to decipher pathophysiological significance of Aryl hydrocarbon Receptor signaling in toxicology and metabolic diseases. This is an excellent opportunity to join a highly integrative, collaborative, and translational research group. For more information about our laboratory please visit: https://www.joshilaboratory.org/

Applicant should hold a Ph.D. in Biomedical Sciences. Preference will be given to the candidates with documented success in terms of first author publications and prior experience in molecular and cellular biology, microscopy, and mouse models. Highly motivated individuals who wish to develop careers in academia or pharmaceutical/toxicology industry are strongly encouraged to apply. Interested applicants should send their CV and a list of three references directly to aditya-joshi@ouhsc.edu. 

Posted 2/5/2024

The Department of Ophthalmology at the University of Oklahoma Health Sciences Center is currently offering two postdoctoral fellow positions in vision research. These positions are funded by an NIH/NEI research grant, focusing on understanding the cellular and molecular mechanisms of photoreceptor degeneration and exploring therapeutic interventions. We are seeking Ph.D. graduates with a strong innovative focus, excellent communication skills, and a proven publication record. Preference will be given to individuals with a strong interest and experience in vision research.

To apply, please send a cover letter, curriculum vitae, and contact information for three references to Dr. Raju Rajala at the Department of Ophthalmology, University of Oklahoma Health Sciences Center, 608 Stanton L. Young Blvd., Oklahoma City, OK 73104. You can also reach Dr. Rajala by phone at (405) 271-8255, by fax at (405) 271-8128, or via email at raju-rajala@ouhsc.edu.

Multiple postdoctoral positions are available at the University of Oklahoma Health Sciences Center in Dr. Prabha Nagareddy’s lab at the Department of Medicine. The successful candidate will utilize molecular, genetic, immunological and pharmacological approaches to decipher the signaling pathways that regulate inflammation with a focus on myeloid cell production in different disease settings, including but not limited to diabetes, obesity, atherosclerosis, myocardial ischemia, etc.

Candidates must be able to design and perform experiments independently with appropriate but minimal supervision. Prior experience in flow cytometry including sorting and data analysis, mouse genetics, animal handling, bioinformatics, confocal microscopy and surgical techniques would be a distinct advantage. Highly motivated individuals who wish to develop careers in academia are encouraged to apply.  Preference will be given to candidates with documented success in research, such as first author publications and aspirations for an independent scientific career.  Please provide your CV, letter of specific research interests, and contact information for 3 references by email to Prabhakara-nagareddy@ouhsc.edu.

Postdoctoral Position in Bone Regeneration and Diabetic and Polycystic Kidney Diseases

A postdoctoral position is available at the University of Oklahoma Health Sciences Center in Dr. Mary Beth Humphrey’s lab to study molecular mechanisms of mesenchymal stem cell regulation and the gut microbiome on bone regeneration. Additional studies include the role of TREM2+ macrophages in kidney diseases.

Candidate should have a Ph.D. ideally with experience in bone biology, immunology, molecular biology, cell biology, or biochemistry.  Experience with mammalian cell culture, recombinant DNA technology, cellular signaling and mouse models are preferred.   Candidate must be able to plan and perform experiments in an independent manner with appropriate supervision, have excellent communication skills and strong interpersonal skills.  Candidate will also be responsible for writing papers, protocols and lab reports associated with this project. Highly motivated individuals who wish to develop careers as independent scientists are encouraged to apply.  Preference will be given to candidates with documented success in research, such as recent first author publications and aspirations for an independent scientific career.  Please provide your CV, letter of interest, and contact information for 3 references, including current employer by email.

Contact via e-mail to marybeth-humphrey@ouhsc.edu.

Job Description---

A postdoctoral fellowship is available in the Pediatric Cardiovascular Research Laboratory of Dr. Harold M. Burkhart, Director of the Pediatric Cardiovascular Surgical program at Oklahoma Children’s Hospital  and the University of Oklahoma Health Sciences Center (OUHSC). This is a multidisciplinary laboratory consisting of collaboration with Dr. Arshid Mir (Director of Pediatric Cardiology) and Dr. Chung-Hao Lee (School of Aerospace and Mechanical Engineering).  We are seeking a highly motivated and independent postdoctoral fellow, with expertise in image-based cardiovascular computational modeling for congenital heart conditions. Dr. Burkhart’s research projects provide opportunities to have major, positive impacts on patients born with congenital heart conditions, such as hypoplastic left heart syndrome (HLHS) and atrioventricular canal defect, by developing patient-specific surgical planning strategies using state-of-the-art computational technologies. The lab also has previously funded projects focusing on stem cell therapy for HLHS, biomechanical and microstructural characterizations of tricuspid heart valve tissue, and in-silico biomechanical modeling for the cardiac valvular systems. 

This is an excellent opportunity to join a highly integrative, translational and productive research group, with high-impact papers in top-tier journals including the Annals of Thoracic Surgery, the Journal of Thoracic and Cardiovascular Surgery, Computer Methods in Applied Mechanics and Engineering, Acta Biomaterialia, and Annals of Biomedical Engineering. The ideal candidate will be reliable, personable, highly motivated, and have demonstrated the ability to work independently. The candidate should be open to explore new opportunities and disciplines. The candidate is also expected to assist in writing grant proposals and will be highly encouraged to submit fellowship applications (both intramural and extramural) in order to help career development.

Other responsibilities will include communicating results to the scientific community through publications and presentations, and supervising graduate students, clinical residents, and laboratory technicians. Weekly attendance and presentation of data at lab meetings is expected. Presentation of results for submission of manuscripts to clinical and/or internationally recognized journals is expected for this position.

Job Requirements---

Our ideal candidate will have:

• A Ph.D. in the field of bioengineering, mechanical engineering, chemical engineering, or similar field
• Prior research experience should include bio-solid/bio-fluid computational modeling and image-based reconstruction of 3D geometry of pediatric cardiovascular systems
• Minimum of 2-3 year(s) experience with finite element analysis
• Experience with Python and/or other programming languages
• Experience with manuscript writing, statistical analysis, and preparation of figures for data/results is required
• Experience with virtual reality, 3D printing, and other techniques for visualizing pediatric hearts and heart valves is a benefit, but not required
• Experience with the scientific process of research study design, IRB approval is preferred
• A strong communication skill
• High level of initiative and technical proficiency and ability to collaborate within a highly interdisciplinary group
• Good record keeping skills and follow safety procedures and maintain a safe work environment

Salary & Benefits:

The position is full-time for one year with the option to extend dependent on the postdoctoral fellow’s performance and available funding. Salary will be based on the NIH stipend scale and will be commensurate with skills and experience. The University of Oklahoma Health Sciences Center (OUHSC) offers postdocs most employee benefits.

Application Instructions:

Applications should submit a CV (with contact information of a minimum of three [3] professional work references) and cover letter in electronic format (only) to Dr. Harold Burkhart, Director of the Pediatric Cardiovascular Surgical program at OUHSC at: harold-burkhart@ouhsc.edu

Questions about the position may be directed to Dr. Harold M. Burkhart harold-burkhart@ouhsc.edu or Dr. Chung-Hao Lee ch.lee@ou.edu

Equal Employment Opportunity Statement: The University of Oklahoma, in compliance with all applicable federal and state laws and regulations, does not discriminate on the basis of race, color, national origin, sex, sexual orientation, genetic information, gender identity, gender expression, age, religion, disability, political beliefs, or status as a veteran in any of its policies, practices, or procedures. This includes, but is not limited to, admissions, employment, financial aid, housing, services in educational programs or activities, and health care services that the University operates or provides.

Hiring contingent upon a Background Check? – Yes

Special Indications: None

Posted: 05/08/23 - Still Active 8/10/2023

12 month termed position; renewable contingent on funding 

Job description 

Biochemistry lab at The University of Oklahoma Health Sciences Center looking for a postdoctoral researcher. The group studies the relationship between brain metabolism and function, with particular emphasis on neuronal bioenergetics in the context of aging and cognitive decline. There will be opportunities to participate in several collaborative efforts aimed at understanding the metabolism of different cell types during aging or diseased states.  

The ideal candidate must be a well-organized and independent scientist with experience in physiology/pharmacology, biochemistry, molecular biology (e.g. plasmids, viral expression vectors, and subcloning), and a strong background in fluorescence microscopy and/or electrophysiology. Hands-on experience related to laboratory animal work is preferred, as well as good record keeping and general laboratory practices including sterile technique. Tissue culture experience is also desired. The selected candidate is expected to maintain respectful and productive interactions with other lab members and collaborators. 

Proposed/Current Job Responsibilities                                                                 % of time spent on each 

Mouse surgery (stereotactic injection of viral vectors)                                                        15% 

Molecular biology procedures / subcloning                                                                           20% 

Microscopy/electrophysiology                                                                                                  50% 

Lab management (ordering, organization)                                                                             10% 

Tissue culture (cell line maintenance and transfection)                                                        5% 

TOTAL                                                                                                                                                   100% 

* The percentages of time spent in each activity may vary depending on the laboratory needs. 

Basic qualifications 

PhD degree or equivalent in Biochemistry, Physiology, Neuroscience or any other related discipline 

Additional qualifications 

Detailed guidance and training will be provided for each of the specific procedures used. All of the work requires focus and attention to detail and creative problem solving. Training and supervision of junior lab members is also expected.

Please submit a cover letter/email (letter of interest), a current CV and contact information for three references to Dr. Diaz Garcia (CarlosManlio-DiazGarcia@ouhsc.edu).

Posted: 04/27/23 - Still Active 8/10/23

The Post-Doctoral Fellow will develop and synthesize small molecule dyes, peptide-based contrast agents, or nanomaterials for cancer imaging and drug delivery applications. The Post-Doctoral Fellow will be responsible for synthesis, development, and evaluation of small molecule dyes (organic synthesis), peptide-based contrast agents, and/or nanomaterials (polymer and silica nanoparticles) to target the tumor microenvironment (breast, pancreatic, ovarian, and colon tumors).  

The Post-Doctoral Fellow will work with existing laboratory members in the development small molecule dyes, peptide-based contrast agents, and/or nanoparticles for drug delivery with applications in cancer and inflammation.  The Post Doc Fellow will work within our multi-disciplinary team to evaluate contrast agent specificity, toxicity, drug/dye release from nanoparticles, or efficacy using both in vitro and in vivo experimentation in murine, swine, and human of solid tumors. The Post Doc will have the opportunity to learn about writing and submitting their own independent federal grants (USA). Other responsibilities will include communicating results to the scientific community through publications and presentations, and supervising graduate students, clinical residents, and laboratory technicians. Weekly attendance and presentation of data at lab meeting is expected. Presentation of results for submission of manuscripts to international journals is expected for this position.

This position is funded by NIH grants.

Our ideal candidate will have:

• A Ph.D. in the field of chemistry, bioengineering, materials science, chemical engineering, biochemistry, biology or similar field;
• Prior research experience should include: organic chemistry, polymer chemistry, nanomaterials, or peptides-based agents
• Experience with standard characterization techniques required;
• Experience with manuscript writing, preparation of figures is required;
• Experience small animals (mice) is a benefit, but not required;
• Broad knowledge and experience in contrast agents and various imaging modalities is a strength;
• Must show technical proficiency and have the ability to collaborate within a multi-disciplinary group;
• Must have good record keeping skills;
• Must follow safety procedures and maintain a safe work environment;
• Strong interpersonal skills and the ability to contribute in a multidisciplinary team setting are mandatory.

Keywords: chemistry, organic chemistry, polymer chemistry, nanomaterials, nanoparticles, material science, contrast agent, imaging

The position is full-time for one year with the option to extend dependent on Post Doc performance and available funding. This project builds upon the work of Dr. Lacey McNally, an NIH funded investigator for the last 14 years. Salary will be based on experience and will use the NIH scale.

Interested candidates must apply online at https://jobs.ou.edu, job number 230418.

“The University of Oklahoma is an Equal Opportunity Institution.  For more information go to www.ou.edu/eoo.”

Posted 3/8/2023 - Still Active 8/10/2023

A postdoctoral fellowship is available in the laboratory of Dr. Jacob E (Jed) Friedman, new Director of the Harold Hamm Diabetes Center at the University of Oklahoma Health Sciences Center. A major leadership gift of $34 million has allowed for the expansion of laboratories and Endowed Chairs for research on developmental origins of disease (DoHAD). We are seeking highly motivated and independent postdoctoral fellows, with expertise in nutrition and the molecular or clinical aspects of obesity, diabetes or its complications, specifically in the liver, adipose biology, or innate immune system.  Dr. Friedman’s research projects provide opportunities to have major, positive impacts on human medicine by investigating how maternal obesity impacts the development of establishment of the innate immune system (bone and liver) and development of obesity and non-alcoholic fatty liver disease in Mouse, Monkey and Man.  The lab also has funded projects focusing on nutrition and microbiome development and biomarkers of disease in humans and mouse models.  

Expertise in assessment of the effects of nutrition on the development of adipose, liver, immunity, or microbiome is desired. Responsibilities will include working with mice, routine cell culture, protein and RNA isolation from cells and tissue, Western blotting, and tools for investigating epigenetics or cell transcriptomics in bone-marrow and liver-derived cells.  The ideal candidate will be reliable, personable, highly motivated, and have demonstrated the ability to work independently. This is an excellent opportunity to join a highly integrative, translational and productive research group, with high impact papers in top journals including PNAS, JCI, Nature Communications, and Cell Reports.

https://medicine.ouhsc.edu/Academic-Departments/Physiology/Faculty/jacob-e-jed-friedman-phd

Dr. Friedman’s lab has state-of-the-art equipment including a Cytation 5 multi-mode imager, a Jess Simple Western system, and a QuantStudio 6 real-time PCR machine. Campus shared resources and cores include: Tissue Banking and Pathology; Biostatistics and Research Design; Mass Spectrometry / Proteomics; DNA Sequencing / Genomics; Flow Cytometry / Imaging; Diabetic Phenotyping; Germ-Free Facility; Non-Human Primates, and Mobile Health (mHealth) Technology Network (NCTN), with robust pilot funding and training grants in diabetes, cancer, gerosciences, and developmental immunology.

Prerequisites:

• Graduation from an accredited college or university with a PhD in nutrition, physiology, immunology, molecular biology, biochemistry, cell biology, or closely related fields
• Minimum of 2-3 year(s) experience in working with in vivo models relevant to obesity.
• Excellent communication skills
• Proven ability to work independently within a research lab.
• Demonstrated proficiency in computer software (Microsoft Office, SAS), standard laboratory equipment operation, and research technical skills

Salary & Benefits: 
Salary will be based on the NIH stipend scale and will be commensurate with skills and experience. The University of Oklahoma Health Sciences Center offers postdocs most employee benefits.  

Applicant Instructions

• Applicants may apply directly to Dr. Jacob Friedman, Director Harold Hamm Diabetes Center at: jed-friedman@ouhsc.edu
• Required application materials:
  • Cover letter
  • Resume/Curriculum Vitae
  • Contact information for a minimum of [3] professional work references

The University of Oklahoma medical campus is committed to providing a safe and productive learning and living community. To achieve that goal, we conduct background investigations for all final applicants being considered for employment. Background investigations include a criminal history record check, and when appropriate, a financial and/or motor vehicle history.

The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. The University of Oklahoma strongly supports the principle of diversity. The University of Oklahoma is an Equal Opportunity Institution. Protected veterans and individuals with disabilities are encouraged to apply.

Please be advised that the University does check references as part of the employment process, and selection committee members may choose to contact work references during the search process other than those listed in your application.

The University of Oklahoma is an Affirmative Action/Equal Opportunity Employer http://www.ou.edu/eoo/ .  Protected veterans and individuals with disabilities are encouraged to apply.

Posted 12/7/2022 - Still Active 8/10/2023

Postdoctoral Position in Radiation Oncology

Position Highlights

The laboratory of Dr. Dinesh Thotala at the at Oklahoma University Health Sciences Center is seeking a highly motivated Postdoctoral Research Fellow with a passion for cancer research and a strong background in immunology. The position offers a competitive salary based on the NIH pay lines.

Projects:

The candidate will investigate the mechanism behind radiation-induced immune suppression and the role of myeloid-derived suppressor cells in tumor immunity. Our laboratory specializes in exploring the cellular and molecular mechanisms that regulate T cell development, differentiation, activation, and effector function.

Responsibilities

The successful candidate will have the following responsibilities:

• Independently drive projects and develop innovative research ideas.
• Design and execute experiments using animal models, as well as experimental techniques in immunology, cell biology, and molecular biology.
• Collaborate effectively with diverse team members, including students, technicians, residents, and fellow postdoctoral researchers.
• Read and stay updated with recent publications and write manuscripts and fellowship applications.
• Present their research at national and international meetings.

Eligibility and requirements:

• A recent Ph.D. graduate in Immunology or a related discipline
• Demonstrated excellence in scholarly publications.
• Hands-on experience with animal models and experimental techniques pertinent to cellular immunology and molecular biology.
• Excellent command of the English language.

Preference:

Proficient in hands-on application of flow cytometry. Skilled in utilizing advanced molecular biology or biochemical techniques. Knowledge about single-cell RNA sequencing, CRISPR-Cas9 technology, genomics, and proteomics would be a plus.

Application Instructions:

To submit your application, kindly send an email to dinesh-thotala@ouhsc.edu  including a cover letter delineating your research interests and demonstrating their compatibility with the laboratory's research objectives. Attach your Curriculum Vitae (CV) and provide contact details for at least two references.

Posted 4/15/2024

A postdoctoral position is available at the University of Oklahoma Health Sciences Center in Dr. Mary Beth Humphrey’s lab to study molecular mechanisms of mesenchymal stem cell regulation and  the role of vagal nerve stimulation in prevent pain and joint destruction in mouse models of osteoarthritis.

Candidate should have a Ph.D. with experience in bone biology, immunology, molecular biology, cell biology, or biochemistry.  Experience with mammalian cell culture, recombinant DNA technology, cellular signaling and mouse models of bone disease are preferred.   Candidate must be able to plan and perform experiments in an independent manner with appropriate supervision, have excellent communication skills and strong interpersonal skills.  Candidate will also be responsible for writing papers, protocols and lab reports associated with this project. Highly motivated individuals who wish to develop careers as independent scientists are encouraged to apply.  Preference will be given to candidates with documented success in research, such as recent first author publications and aspirations for an independent scientific career.  Please provide your CV, letter of interest, and contact information for 3 references, including current employer by email.

Contact via e-mail to marybeth-humphrey@ouhsc.edu.

Posted 9/28/22

A postdoctoral position at the Stephenson Cancer Center, University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City, Oklahoma, is immediately available to study chronic lymphocytic leukemia (CLL) biology and signaling involving crosstalk of the malignant cells with the CLL tumor microenvironment.

A highly motivated scientist with a fresh PhD is encouraged to apply. Candidates with experience in cancer biology, molecular biology, and animal models (xenograft as well as transgenic) are preferred. The candidate should have first-hand experience in routine laboratory techniques including but not limited to cell culture, western blots, immunoprecipitation, apoptosis assays, confocal microscopy, PCR/qRT-PCR and other related biochemical assays. Experience in flow cytometry will be an added qualification.

To apply, please send a cover letter stating your research interests and experience along with a curriculum vitae and three references to asish-ghosh@ouhsc.edu.

The Stephenson Cancer Center is an NCI-designated cancer center with interacting teams of scientists supported by an array of core facilities and located on a large OUHSC research campus. OUHSC is one of only four comprehensive academic health centers in the nation with seven health professional schools, providing a broad base of expertise for comprehensive clinical and basic science research, interdisciplinary interaction, and career development. Oklahoma City is a large metropolis with western charm, easy local transportation, vibrant downtown, and excellent suburbs.

Posted: 7/6/22

A lab in University of Oklahoma Health Sciences Center (OUHSC) has an open position for a postdoctoral fellowship in cardiovascular drug development. Applicants with a strong background in cardiovascular research, including rodent model development, cell culture, advanced biochemical techniques, HPLC, etc. are especially encouraged. The successful candidate will be part of a dynamic lab with synergistic skills and experiences and will be given the opportunity to develop new projects that complement the overall directions of the lab. This is a mentored position where incumbents plan, design and conduct research experiments, manage research projects, prepare reports and papers for publication, presentation and future research. The fellow will actively contribute to grant writing and will be encouraged to write applications for independent fellowships. An ideal candidate will have Ph.D. in a biological science, chemistry, or other relevant area, or M.D., or equivalent. History of work in myocardial infarction and/or stroke mouse models preferred. Publication of at least 2-3 peer-reviewed articles is expected. Experience planning and effectively executing animal projects and maintaining animal colonies, surgical techniques, Western blotting, RT-PCR, Flow cytometry and other advanced molecular techniques. Must have the ability to multitask and work both independently and as a member of an interdisciplinary team with attention to detail.

Benchmark Expectations

• ·       Conduct scientific research.
• ·       Manage research projects and maintain documentation.
• ·       Present scientific information both formally and informally.
• ·       Prepare papers for publication and contribute to grant writing.
• ·       Perform lab management responsibilities as assigned.
• ·       Work collaboratively and collegially as part of the team while developing skills needed as an independent scientist.
• ·       Have experience and/or exposure to cardiovascular or a closely related field.

To apply, please send your current cv and a list of three references (email and phone number) to vawasthi@ouhsc.edu.

Posted 10/04/2021 - Still Active 8/10/2023

A postdoctoral position is available immediately in the Department of Biochemistry and Molecular Biology and the Center for Geroscience and Healthy Brain Aging at the University of Oklahoma Health Sciences Center.  The applicant will work on mechanisms of pathogenesis of Alzheimer’s disease (AD) and related dementias using rodent models, with a specific focus on the role of mechanisms of aging, pathogenic tau, and cerebrovascular pathways of AD.  For more information please see the laboratory’s website https://www.galvanlab.org.

The successful candidate should hold a Ph.D. in neuroscience, biochemistry, genetics, cellular or molecular biology, physiology, or other related fields and have a record of creativity and strong scientific productivity. Working experience on mouse models, assessment of brain vascular function, optical imaging, primary neuron cell culture, molecular biology and mouse genetics, and a background in neuroscience and brain vascular biology are strongly preferred, but not exclusively required. Please provide a curriculum vitae, a brief summary of research experience and goals, and the names and contact information of three references to Dr. Veronica Galvan (galvanv@uthscsa.edu) or to Dr. William Sonntag (william-sonntag@ouhsc.edu) on behalf of Dr. Veronica Galvan.

Posted: June 23, 2021