The Harold Hamm Diabetes Center (HHDC) at the University of Oklahoma (OU) invites applications for a postdoctoral research associate position in computational biology and bioinformatics. HHDC has an exceptional and expanding research program focusing on the early origins of diabetes and obesity in children. The candidate will be co-mentored by HHDC Member, Dr. Chongle Pan, and HHDC Director, Dr. Jacob E. Friedman. Dr. Pan is an Associate Professor in the School of Computer Science and the Department of Microbiology and Plant Biology in OU Norman. Dr. Friedman is a Professor of Physiology, Biochemistry & Molecular Biology, and Pediatrics & Medicine at OU Health Sciences Center.
They have formed an active ongoing collaboration and partnership for tools ranging from transcriptomics, metabolomics, epigenetics, to metagenomics of the microbiome.
The research will focus on the characterization of risk factors for diabetes in early childhood. The risk factors will include childhood microbiota dysbiosis, genetic predisposition, and maternal metabolism disorders. Key molecular determinants for these risk factors will be identified from multi-omics data, which will be used to develop testable hypotheses for follow-on molecular biology experiments and build computational models for predicting and understanding diabetes.
The candidate is responsible for analyzing and mining multi-omics data using computational techniques, such as machine learning, generalized linear mixed models, and biological network analysis. This may require development of new computer algorithms and/or construction of computational workflows on computer clusters. The types of multi-omics data will include longitudinal metagenomics sequencing data, genome-wide association (GWAS) data, proteomics data, and metabolomics data. The candidate is expected to publish their findings in peer-reviewed journals.
- Ph.D. in bioinformatics, computer science, or a related field.
- Strong publication track record
- Relevant prior research experience
Applicants should submit CV and cover letter in electronic format (only) to Patricia-Parker@ouhsc.edu
Questions about the position may be directed to Dr. Chongle Pan at firstname.lastname@example.org or Dr. Jacob Friedman at email@example.com
The University of Oklahoma is an Affirmative Action/Equal Opportunity Employer http://www.ou.edu/eoo/ . Protected veterans and individuals with disabilities are encouraged to apply.
A postdoctoral fellowship is available in the laboratory of Dr. Jacob E (Jed) Friedman, new Director of the Harold Hamm Diabetes Center at the University of Oklahoma Health Sciences Center. A major leadership gift of $34 million has allowed for the expansion of laboratories and Endowed Chairs for research on developmental origins of disease (DoHAD). We are seeking highly motivated and independent postdoctoral fellows, with expertise in nutrition and the molecular or clinical aspects of obesity, diabetes or its complications, specifically in the liver, adipose biology, or innate immune system. Dr. Friedman’s research projects provide opportunities to have major, positive impacts on human medicine by investigating how maternal obesity impacts the development of establishment of the innate immune system (bone and liver) and development of obesity and non-alcoholic fatty liver disease in Mouse, Monkey and Man. The lab also has funded projects focusing on nutrition and microbiome development and biomarkers of disease in humans and mouse models.
Expertise in assessment of the effects of nutrition on the development of adipose, liver, immunity, or microbiome is desired. Responsibilities will include working with mice, routine cell culture, protein and RNA isolation from cells and tissue, Western blotting, and tools for investigating epigenetics or cell transcriptomics in bone-marrow and liver-derived cells. The ideal candidate will be reliable, personable, highly motivated, and have demonstrated the ability to work independently. This is an excellent opportunity to join a highly integrative, translational and productive research group, with high impact papers in top journals including PNAS, JCI, Nature Communications, and Cell Reports.
Dr. Friedman’s lab has state-of-the-art equipment including a Cytation 5 multi-mode imager, a Jess Simple Western system, and a QuantStudio 6 real-time PCR machine. Campus shared resources and cores include: Tissue Banking and Pathology; Biostatistics and Research Design; Mass Spectrometry / Proteomics; DNA Sequencing / Genomics; Flow Cytometry / Imaging; Diabetic Phenotyping; Germ-Free Facility; Non-Human Primates, and Mobile Health (mHealth) Technology Network (NCTN), with robust pilot funding and training grants in diabetes, cancer, gerosciences, and developmental immunology.
- Graduation from an accredited college or university with a PhD in nutrition, physiology, immunology, molecular biology, biochemistry, cell biology, or closely related fields
- Minimum of 2-3 year(s) experience in working with in vivo models relevant to obesity.
- Excellent communication skills
- Proven ability to work independently within a research lab.
- Demonstrated proficiency in computer software (Microsoft Office, SAS), standard laboratory equipment operation, and research technical skills
Salary & Benefits:
Salary will be based on the NIH stipend scale and will be commensurate with skills and experience. The University of Oklahoma Health Sciences Center offers postdocs most employee benefits.
- Applicants may apply directly to Dr. Jacob Friedman, Director Harold Hamm Diabetes Center at: firstname.lastname@example.org
- Required application materials:
- Cover letter
- Resume/Curriculum Vitae
- Contact information for a minimum of  professional work references
The University of Oklahoma medical campus is committed to providing a safe and productive learning and living community. To achieve that goal, we conduct background investigations for all final applicants being considered for employment. Background investigations include a criminal history record check, and when appropriate, a financial and/or motor vehicle history.
The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. The University of Oklahoma strongly supports the principle of diversity. The University of Oklahoma is an Equal Opportunity Institution. Protected veterans and individuals with disabilities are encouraged to apply.
Please be advised that the University does check references as part of the employment process, and selection committee members may choose to contact work references during the search process other than those listed in your application.
The University of Oklahoma is an Affirmative Action/Equal Opportunity Employer http://www.ou.edu/eoo/ . Protected veterans and individuals with disabilities are encouraged to apply.
We are seeking a highly motivated and dedicated scientist with a deep understanding of immunology to join our team investigating mechanisms of radiation-induced immune and inflammatory responses. The candidate should be open to explore new opportunities and disciplines. The post-doctoral scientist will work at Oklahoma University in the department of Radiation Oncology.
The appointee will work on the elucidation of the mechanism of Radiation-induced immune suppression using a combination of immunology, molecular biology, and genetics/genomics approaches. The project will focus on T cell development, inflammation and immunity and would need knowledge in variety of immunological assays and biological systems. The project is translational and highly collaborative.
- A recent graduate with a PhD in Immunology or a related field
- A strong publication record
- Ability to design and conduct experiments independently
- Ability to work with others as a team
- Required to read new publications and write manuscripts and fellowship applications.
- Present their research at national and international meetings.
- Excellent command of the English language.
- Experience with mouse models and cellular immunology.
- Radiation biology or stem cell biology
- Experience with advanced molecular biology or biochemical techniques such as single cell RNA seq, CRISPR-Cas9 technology, genomics and/or proteomics.
While funding will be provided for this position, the appointee will be encouraged to write and apply for outside funding in order to help career development.
Interested applicants should send a cover letter highlighting prior experience and CV to
A postdoctoral position is available at the University of Oklahoma Health Sciences Center in Dr. Mary Beth Humphrey’s lab to study molecular mechanisms of mesenchymal stem cell regulation and the role of vagal nerve stimulation in prevent pain and joint destruction in mouse models of osteoarthritis.
Candidate should have a Ph.D. with experience in bone biology, immunology, molecular biology, cell biology, or biochemistry. Experience with mammalian cell culture, recombinant DNA technology, cellular signaling and mouse models of bone disease are preferred. Candidate must be able to plan and perform experiments in an independent manner with appropriate supervision, have excellent communication skills and strong interpersonal skills. Candidate will also be responsible for writing papers, protocols and lab reports associated with this project. Highly motivated individuals who wish to develop careers as independent scientists are encouraged to apply. Preference will be given to candidates with documented success in research, such as recent first author publications and aspirations for an independent scientific career. Please provide your CV, letter of interest, and contact information for 3 references, including current employer by email.
Contact via e-mail to email@example.com.
A position for a post-doctoral fellow is available in the laboratory of Dr. Carol Webb in the Department of Medicine, Division of Rheumatology, Immunology and Allergy at the University of Oklahoma Health Sciences Center in Oklahoma City. We are seeking a highly motivated person with an outstanding work ethic. Funded projects seek to determine mechanisms for autoimmune activation in human blood cells and for development of kidney organoid cultures from adult stem cells. Prior experience with tissue culture, flow cytometry and molecular biology would be beneficial. Successful candidates will have strong oral and written communication and organization skills. The environment at OUHSC is diverse and inclusive.
To apply, email a cover letter describing research interests, a CV and names and contact information of three references directly to Dr. Webb at firstname.lastname@example.org.
The Hannafon Laboratory at the University of Oklahoma Health Sciences Center is seeking a postdoctoral fellow to study drug development and anti-tumor targeting mechanisms of a novel therapeutic combination in breast cancer. The successful candidate should be a highly ambitious and self-motivated scientist with good organization skills, and excellent written and verbal communication skills.
The research focus of the Hannafon laboratory is to discover and investigate the molecular mechanisms of breast and gynecologic cancer development, progression, therapeutic response, and resistance. We are especially interested in the role of small extracellular vesicles, known as exosomes, in intercellular communication in the tumor microenvironment, and evaluate their use as biomarkers. An additional focus of the laboratory is anti-cancer drug development for improved targeting and therapeutic response in gynecologic and breast cancers.
Interested candidates should send a CV, a brief one-paragraph description of previous research experience, and a list of 3 references to Bethanyemail@example.com
Teamwork: Being a good laboratory member and working collaboratively with others.
Cell culture. Maintain cell cultures and reagents, and cell line inventories. Conduct experiments to analyze the effects of treatments using various assays.
Animal Testing. Must Perform specialized tests on experimental animals including tumor cell injection, weighing, administration of drugs, maintaining a census, and surgeries in mice models.
Molecular, Cellular, and Biochemical Analysis. Perform a variety of assays on cell cultures, and human or animal tissues, including DNA/RNA/protein extraction, PCR, growth assays, immunoblotting, and other specific routine assays, as required.
Data Collection and Maintenance. Enter, compile and graph data, maintain a laboratory notebook, and file reports. May perform data analysis.
Equipment Maintenance. Maintain laboratory space, laboratory supplies, and equipment, assesses lab group needs to order and stock supplies and equipment.
And as Needed. Perform various duties as needed to successfully fulfill the function of the position.
The candidate will be expected to perform research, write manuscripts, and present findings at local and national meetings. The candidate will also assist in writing grant proposals and will be highly encouraged to submit fellowship applications (both intramural and extramural).
Previous experience in Animal handling and willingness to work with mice.
Please submit the following documents to Bethanyfirstname.lastname@example.org
- One paragraph description of previous research experience
- List of 3 professional references.
Remains valid as of 9/5/22
A postdoctoral position is immediately available in the Yue laboratory in the Department of Pharmaceutical Sciences, College of Pharmacy at the University of Oklahoma Health Sciences Center. The Yue laboratory is seeking a highly motivated postdoctoral fellow to conduct NIH-funded projects on drug transport proteins. The postdoctoral fellow will study the role and regulation of organic anion transport polypeptide (OATP1B1) and OATP1B3 in drug disposition, aiming to mitigate transporter-mediated drug-drug and drug-disease interactions. Drug transport protein-related research has grown exponentially in the past decade driven by the emergence of the Food and Drug Administration (FDA) Critical Path Initiative and subsequent white papers (Nat Rev Drug Discovery, 2010, 9: 215; Clin Pharmacol Ther, 2018, 104:890; Clin Pharmacol Ther, 2022, 112: 461) and the guidance for industry from the US FDA (https://www.fda.gov/media/134582/download). Multi-disciplinary approaches are utilized in the Yue research program. These approaches include 1) sandwich-cultured primary human hepatocytes; 2) gene-knockout models; 3) proteomics; 4) molecular and cell biology approaches, including confocal microscopy; 5) pharmacogenomics studies; and 6) physiologically-based pharmacokinetic (PBPK) modeling and simulation. For more information, visit https://sites.google.com/view/yuelab
Successful candidates should have a Ph.D. in Cell Biology, Molecular Biology, Pharmaceutical Sciences, Pharmacology, Biochemistry, Immunology, or a related field. Preference will be given to applicants with at least one first-author publication in a reputable journal. Required qualifications are Ph.D., M.D., or Ph.D./M.D. Experience in mammalian cell culture, aseptic technique, and standard cell and molecular biology techniques, including DNA/RNA extraction and immunoblot, are required. Experience with real-time RT-PCR is preferred, but not required. Individuals with experience in protein post-translational modifications and epigenetics are particularly encouraged to apply. Competitive candidates are expected to have excellent oral and written communication skills. Review of applications will begin immediately and the position will remain open until filled. To apply, please send the following materials: a cover letter containing a brief summary of the applicant’s current research, research interests, and career goals; curriculum vitae/resume; contact information for three references; and reprints of the applicant’s publications to Dr. Wei Yue, email@example.com.
A postdoctoral position at the Stephenson Cancer Center, University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City, Oklahoma, is immediately available to study chronic lymphocytic leukemia (CLL) biology and signaling involving crosstalk of the malignant cells with the CLL tumor microenvironment.
A highly motivated scientist with a fresh PhD is encouraged to apply. Candidates with experience in cancer biology, molecular biology, and animal models (xenograft as well as transgenic) are preferred. The candidate should have first-hand experience in routine laboratory techniques including but not limited to cell culture, western blots, immunoprecipitation, apoptosis assays, confocal microscopy, PCR/qRT-PCR and other related biochemical assays. Experience in flow cytometry will be an added qualification.
To apply, please send a cover letter stating your research interests and experience along with a curriculum vitae and three references to firstname.lastname@example.org.
The Stephenson Cancer Center is an NCI-designated cancer center with interacting teams of scientists supported by an array of core facilities and located on a large OUHSC research campus. OUHSC is one of only four comprehensive academic health centers in the nation with seven health professional schools, providing a broad base of expertise for comprehensive clinical and basic science research, interdisciplinary interaction, and career development. Oklahoma City is a large metropolis with western charm, easy local transportation, vibrant downtown, and excellent suburbs.
The University of Oklahoma Health Sciences Center is an Equal Opportunity/Affirmative Action employer that is strongly and actively committed to diversity within its community. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, political beliefs, national origin, age (40 or older), sex (see: Sexual Misconduct, Discrimination policy) sexual orientation, genetic information, gender identity, gender expression, disability, or veteran status.
A lab in University of Oklahoma Health Sciences Center (OUHSC) has an open position for a postdoctoral fellowship in cardiovascular drug development. Applicants with a strong background in cardiovascular research, including rodent model development, cell culture, advanced biochemical techniques, HPLC, etc. are especially encouraged. The successful candidate will be part of a dynamic lab with synergistic skills and experiences and will be given the opportunity to develop new projects that complement the overall directions of the lab. This is a mentored position where incumbents plan, design and conduct research experiments, manage research projects, prepare reports and papers for publication, presentation and future research. The fellow will actively contribute to grant writing and will be encouraged to write applications for independent fellowships. An ideal candidate will have Ph.D. in a biological science, chemistry, or other relevant area, or M.D., or equivalent. History of work in myocardial infarction and/or stroke mouse models preferred. Publication of at least 2-3 peer-reviewed articles is expected. Experience planning and effectively executing animal projects and maintaining animal colonies, surgical techniques, Western blotting, RT-PCR, Flow cytometry and other advanced molecular techniques. Must have the ability to multitask and work both independently and as a member of an interdisciplinary team with attention to detail.
- · Conduct scientific research.
- · Manage research projects and maintain documentation.
- · Present scientific information both formally and informally.
- · Prepare papers for publication and contribute to grant writing.
- · Perform lab management responsibilities as assigned.
- · Work collaboratively and collegially as part of the team while developing skills needed as an independent scientist.
- · Have experience and/or exposure to cardiovascular or a closely related field.
To apply, please send your current cv and a list of three references (email and phone number) to email@example.com.
The incumbent will perform research using microbiological, molecular and cellular techniques as well as collaborating with others to perform neuro-cognitive assessments to neuroinflammation and its effects on cognitive function, particularly in the context of aging. Full job description is here.
Inquiries and Applications: Dr Doug Drevets Douglas-Drevets@ouhsc.edu with a cc to Wendy Newport, Section Manager.
Posted 9/10/21 (Remains active as of 9/1/22)
A postdoctoral position is available immediately in the Department of Biochemistry and Molecular Biology and the Center for Geroscience and Healthy Brain Aging at the University of Oklahoma Health Sciences Center. The applicant will work on mechanisms of pathogenesis of Alzheimer’s disease (AD) and related dementias using rodent models, with a specific focus on the role of mechanisms of aging, pathogenic tau, and cerebrovascular pathways of AD. For more information please see the laboratory’s website https://www.galvanlab.org.
The successful candidate should hold a Ph.D. in neuroscience, biochemistry, genetics, cellular or molecular biology, physiology, or other related fields and have a record of creativity and strong scientific productivity. Working experience on mouse models, assessment of brain vascular function, optical imaging, primary neuron cell culture, molecular biology and mouse genetics, and a background in neuroscience and brain vascular biology are strongly preferred, but not exclusively required. Please provide a curriculum vitae, a brief summary of research experience and goals, and the names and contact information of three references to Dr. Veronica Galvan (firstname.lastname@example.org) or to Dr. William Sonntag (email@example.com) on behalf of Dr. Veronica Galvan.
Posted: June 23, 2021
The Benbrook Research Group at the University of Oklahoma Health Sciences Center is recruiting a post-doctoral fellow who is collaborative and interested in researching anti-cancer drug development against Gynecological Cancers. Interested candidates should send a CV, a brief one paragraph description of previous research experience, and a list of 3 references to Doris-Benbrook@ouhsc.edu; Vishal-Chandra@ouhsc.edu; Rajani-Rai@ouhsc.edu
Cell culture. Maintain cell cultures and reagents, cell line inventories and conduct experiments to analyze effects of treatments using various assays. Animal Testing. Must Perform specialized tests on experimental animals including tumor cell injection, weighing, administration of drugs, maintaining a census, and surgeries in rat or mice models. Molecular, Cellular and Biochemical Analysis. Perform a variety of assays on cell cultures, and human or animal tissues, including DNA/RNA/protein extraction, PCR, growth assays, immunoblotting, and other specific routine assays, as required. Data Collection and Maintenance. Enter, compile and graph data, maintain laboratory notebook and file reports. May perform data analysis. Equipment Maintenance. Maintain laboratory space, laboratory supplies and equipment, assesses lab group needs to order and stock supplies and equipment. And as Needed. Perform various duties as needed to successfully fulfill the function of the position.
Candidate will be expected to perform research, write manuscripts, and present findings at local and national meetings. Candidate will also assist in writing grant proposals and will be highly encouraged to submit fellowship applications (both intramural and extramural).
- Previous experience in Animal handling and willing to work with rats, mice.
Posted: June 18, 2021 (Remains active as of 9/1/22)