The Harold Hamm Diabetes Center (HHDC) at the University of Oklahoma (OU) invites applications for a postdoctoral research associate position in computational biology and bioinformatics. HHDC has an exceptional and expanding research program focusing on the early origins of diabetes and obesity in children. The candidate will be co-mentored by HHDC Member, Dr. Chongle Pan, and HHDC Director, Dr. Jacob E. Friedman. Dr. Pan is an Associate Professor in the School of Computer Science and the Department of Microbiology and Plant Biology in OU Norman. Dr. Friedman is a Professor of Physiology, Biochemistry & Molecular Biology, and Pediatrics & Medicine at OU Health Sciences Center.
They have formed an active ongoing collaboration and partnership for tools ranging from transcriptomics, metabolomics, epigenetics, to metagenomics of the microbiome.
https://medicine.ouhsc.edu/Academic-Departments/Physiology/Faculty/jacob-e-jed-friedman-phd
http://www.ou.edu/coe/cs/people/pan
http://www.ou.edu/cas/mpbio/people/faculty/pan
The research will focus on the characterization of risk factors for diabetes in early childhood. The risk factors will include childhood microbiota dysbiosis, genetic predisposition, and maternal metabolism disorders. Key molecular determinants for these risk factors will be identified from multi-omics data, which will be used to develop testable hypotheses for follow-on molecular biology experiments and build computational models for predicting and understanding diabetes.
Job Responsibilities:
The candidate is responsible for analyzing and mining multi-omics data using computational techniques, such as machine learning, generalized linear mixed models, and biological network analysis. This may require development of new computer algorithms and/or construction of computational workflows on computer clusters. The types of multi-omics data will include longitudinal metagenomics sequencing data, genome-wide association (GWAS) data, proteomics data, and metabolomics data. The candidate is expected to publish their findings in peer-reviewed journals.
Qualifications:
- Ph.D. in bioinformatics, computer science, or a related field.
- Strong publication track record
- Relevant prior research experience
Application Instructions:
Applicants should submit CV and cover letter in electronic format (only) to Patricia-Parker@ouhsc.edu
Questions about the position may be directed to Dr. Chongle Pan at cpan@ou.edu or Dr. Jacob Friedman at jed-friedman@ouhsc.edu
The University of Oklahoma is an Affirmative Action/Equal Opportunity Employer http://www.ou.edu/eoo/ . Protected veterans and individuals with disabilities are encouraged to apply.
Posted 12/7/2022
Postdoctoral Position in Bone Regeneration and Diabetic and Polycystic Kidney Diseases
A postdoctoral position is available at the University of Oklahoma Health Sciences Center in Dr. Mary Beth Humphrey’s lab to study molecular mechanisms of mesenchymal stem cell regulation and the gut microbiome on bone regeneration. Additional studies include the role of TREM2+ macrophages in kidney diseases.
Candidate should have a Ph.D. ideally with experience in bone biology, immunology, molecular biology, cell biology, or biochemistry. Experience with mammalian cell culture, recombinant DNA technology, cellular signaling and mouse models are preferred. Candidate must be able to plan and perform experiments in an independent manner with appropriate supervision, have excellent communication skills and strong interpersonal skills. Candidate will also be responsible for writing papers, protocols and lab reports associated with this project. Highly motivated individuals who wish to develop careers as independent scientists are encouraged to apply. Preference will be given to candidates with documented success in research, such as recent first author publications and aspirations for an independent scientific career. Please provide your CV, letter of interest, and contact information for 3 references, including current employer by email.
Contact via e-mail to marybeth-humphrey@ouhsc.edu.
Job Description---
A postdoctoral fellowship is available in the Pediatric Cardiovascular Research Laboratory of Dr. Harold M. Burkhart, Director of the Pediatric Cardiovascular Surgical program at Oklahoma Children’s Hospital and the University of Oklahoma Health Sciences Center (OUHSC). This is a multidisciplinary laboratory consisting of collaboration with Dr. Arshid Mir (Director of Pediatric Cardiology) and Dr. Chung-Hao Lee (School of Aerospace and Mechanical Engineering). We are seeking a highly motivated and independent postdoctoral fellow, with expertise in image-based cardiovascular computational modeling for congenital heart conditions. Dr. Burkhart’s research projects provide opportunities to have major, positive impacts on patients born with congenital heart conditions, such as hypoplastic left heart syndrome (HLHS) and atrioventricular canal defect, by developing patient-specific surgical planning strategies using state-of-the-art computational technologies. The lab also has previously funded projects focusing on stem cell therapy for HLHS, biomechanical and microstructural characterizations of tricuspid heart valve tissue, and in-silico biomechanical modeling for the cardiac valvular systems.
This is an excellent opportunity to join a highly integrative, translational and productive research group, with high-impact papers in top-tier journals including the Annals of Thoracic Surgery, the Journal of Thoracic and Cardiovascular Surgery, Computer Methods in Applied Mechanics and Engineering, Acta Biomaterialia, and Annals of Biomedical Engineering. The ideal candidate will be reliable, personable, highly motivated, and have demonstrated the ability to work independently. The candidate should be open to explore new opportunities and disciplines. The candidate is also expected to assist in writing grant proposals and will be highly encouraged to submit fellowship applications (both intramural and extramural) in order to help career development.
Other responsibilities will include communicating results to the scientific community through publications and presentations, and supervising graduate students, clinical residents, and laboratory technicians. Weekly attendance and presentation of data at lab meetings is expected. Presentation of results for submission of manuscripts to clinical and/or internationally recognized journals is expected for this position.
Job Requirements---
Our ideal candidate will have:
- A Ph.D. in the field of bioengineering, mechanical engineering, chemical engineering, or similar field
- Prior research experience should include bio-solid/bio-fluid computational modeling and image-based reconstruction of 3D geometry of pediatric cardiovascular systems
- Minimum of 2-3 year(s) experience with finite element analysis
- Experience with Python and/or other programming languages
- Experience with manuscript writing, statistical analysis, and preparation of figures for data/results is required
- Experience with virtual reality, 3D printing, and other techniques for visualizing pediatric hearts and heart valves is a benefit, but not required
- Experience with the scientific process of research study design, IRB approval is preferred
- A strong communication skill
- High level of initiative and technical proficiency and ability to collaborate within a highly interdisciplinary group
- Good record keeping skills and follow safety procedures and maintain a safe work environment
Salary & Benefits:
The position is full-time for one year with the option to extend dependent on the postdoctoral fellow’s performance and available funding. Salary will be based on the NIH stipend scale and will be commensurate with skills and experience. The University of Oklahoma Health Sciences Center (OUHSC) offers postdocs most employee benefits.
Application Instructions:
Applications should submit a CV (with contact information of a minimum of three [3] professional work references) and cover letter in electronic format (only) to Dr. Harold Burkhart, Director of the Pediatric Cardiovascular Surgical program at OUHSC at: harold-burkhart@ouhsc.edu
Questions about the position may be directed to Dr. Harold M. Burkhart harold-burkhart@ouhsc.edu or Dr. Chung-Hao Lee ch.lee@ou.edu
Diversity Statement: The University of Oklahoma is committed to achieving a diverse, equitable, and inclusive university community by recognizing each person's unique contributions, background, and perspectives. The University of Oklahoma strives to cultivate a sense of belonging and emotional support for all, recognizing that fostering an inclusive environment for all is vital in the pursuit of academic and inclusive excellence in all aspects of our institutional mission.
Equal Employment Opportunity Statement: The University of Oklahoma, in compliance with all applicable federal and state laws and regulations, does not discriminate on the basis of race, color, national origin, sex, sexual orientation, genetic information, gender identity, gender expression, age, religion, disability, political beliefs, or status as a veteran in any of its policies, practices, or procedures. This includes, but is not limited to, admissions, employment, financial aid, housing, services in educational programs or activities, and health care services that the University operates or provides.
Hiring contingent upon a Background Check? – Yes
Special Indications: None
05/08/23
12 month termed position; renewable contingent on funding
Job description
Biochemistry lab at The University of Oklahoma Health Sciences Center looking for a postdoctoral researcher. The group studies the relationship between brain metabolism and function, with particular emphasis on neuronal bioenergetics in the context of aging and cognitive decline. There will be opportunities to participate in several collaborative efforts aimed at understanding the metabolism of different cell types during aging or diseased states.
The ideal candidate must be a well-organized and independent scientist with experience in physiology/pharmacology, biochemistry, molecular biology (e.g. plasmids, viral expression vectors, and subcloning), and a strong background in fluorescence microscopy and/or electrophysiology. Hands-on experience related to laboratory animal work is preferred, as well as good record keeping and general laboratory practices including sterile technique. Tissue culture experience is also desired. The selected candidate is expected to maintain respectful and productive interactions with other lab members and collaborators.
Proposed/Current Job Responsibilities % of time spent on each
Mouse surgery (stereotactic injection of viral vectors) 15%
Molecular biology procedures / subcloning 20%
Microscopy/electrophysiology 50%
Lab management (ordering, organization) 10%
Tissue culture (cell line maintenance and transfection) 5%
TOTAL 100%
* The percentages of time spent in each activity may vary depending on the laboratory needs.
Basic qualifications
PhD degree or equivalent in Biochemistry, Physiology, Neuroscience or any other related discipline
Additional qualifications
Detailed guidance and training will be provided for each of the specific procedures used. All of the work requires focus and attention to detail and creative problem solving. Training and supervision of junior lab members is also expected.
Please submit a cover letter/email (letter of interest), a current CV and contact information for three references to Dr. Diaz Garcia (CarlosManlio-DiazGarcia@ouhsc.edu).
04/27/23
A postdoctoral position is available at the University of Oklahoma Health Sciences Center in the lab of Dr. Stavros Stavrakis.
Our translational research is innovative and aims to:
- Investigate neuroimmune communications in heart failure with preserved ejection fraction (HFpEF).
- Investigate the effects of autonomic modulation on autonomic ganglia in humans.
A strong funding history of the PI, close mentorship, state-of-the art laboratory equipment, and strong core facilities provide an outstanding research environment for this position.
The candidate should be self-motivated, hard-working and have a solid background in standard molecular and biological techniques. Experience with cell culture, RNA sequencing, and rodent models of disease is preferred. The candidate must be able to plan and perform experiments in an independent manner with appropriate supervision, have excellent communication skills and strong interpersonal skills. Candidate will also be responsible for writing papers, protocols and lab reports associated with this project. Highly motivated individuals who wish to develop careers as independent scientists are encouraged to apply. Preference will be given to candidates with documented success in research, such as recent first author publications and aspirations for an independent scientific career.
Please provide a letter of application, CV and contact information for 3 references, including current employer by email. Contact via e-mail to Stavros-stavrakis@ouhsc.edu or by US mail, Stavros Stavrakis, MD, PhD; Associate Professor of Medicine; University of Oklahoma Health Sciences Center; 800 Stanton L Young Blvd; Suite 5400; Oklahoma City, OK 73104. Office phone: 405-271-4742 x37517; Fax 405-271-7455.
03/28/23
Two postdoctoral fellow positions are available immediately in the lab of Dr. Kelly Standifer in the Department of Pharmaceutical Sciences, OU College of Pharmacy at the University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City. Our lab studies the role of Nociceptin/Orphanin FQ in traumatic brain injury (TBI) and traumatic stress using several rodent models of TBI and PTSD. We have a special interest in understanding how NOP receptors modulate pain, anxiety-like behaviors, cerebral blood flow, vestibulomotor function and cognition in male and female rats, and in testing and developing novel therapeutic agents to treat these disorders. We seek two motivated post-doctoral fellows with experience in pharmacology and neuroscience and a strong interest in preclinical drug development efforts. The ideal candidates will be excellent written and oral communicators and have hands-on experience in rodent behavioral assays and traumatic brain injury models. Fellows will have the opportunity to learn, design and perform pharmacokinetic in vivo studies, PET/CT imaging, qPCR, immunoblotting and immunohistochemistry. Successful candidates will be expected to work as part of team, perform research, write manuscripts, and present their findings at local and national meetings. The candidate also will assist in writing progress reports, grant proposals, and will be highly encouraged to submit fellowship applications (both intramural and extramural).
The Department of Pharmaceutical Sciences offers a highly collaborative, training and research environment in drug discovery and development, neuroscience, pharmaceutics and drug delivery, immunology, chemistry and radiochemistry and nuclear imaging. OUHSC has a very dynamic and rapidly growing neuroscience community and is an excellent training environment for postdoctoral fellows and the Oklahoma City metro is a vibrant, affordable, and friendly place to live.
Information on being a postdoc at OUHSC in Oklahoma City can be found at https://graduate.ouhsc.edu/Postdoctoral-Fellows
Required Qualifications
Ph.D., M.D. or equivalent terminal or doctoral degree.
Preferred Qualifications
- Doctoral degree in the biological sciences, or in related disciplines.
- Prior experience in working with rodents, and a broad understanding in neuroscience and brain injury, is strongly preferred.
Salary Range
Salary will be based on NIH scale.
Interested candidates should email their curriculum vitae, a letter of interest outlining experience and research goals, and the names and contact information of at least three references to Dr. Kelly Standifer at Kelly-standifer@ouhsc.edu or call 405-271-6593, x47333.
03/20/23
The Post-Doctoral Fellow will develop and synthesize small molecule dyes, peptide-based contrast agents, or nanomaterials for cancer imaging and drug delivery applications. The Post-Doctoral Fellow will be responsible for synthesis, development, and evaluation of small molecule dyes (organic synthesis), peptide-based contrast agents, and/or nanomaterials (polymer and silica nanoparticles) to target the tumor microenvironment (breast, pancreatic, ovarian, and colon tumors).
The Post-Doctoral Fellow will work with existing laboratory members in the development small molecule dyes, peptide-based contrast agents, and/or nanoparticles for drug delivery with applications in cancer and inflammation. The Post Doc Fellow will work within our multi-disciplinary team to evaluate contrast agent specificity, toxicity, drug/dye release from nanoparticles, or efficacy using both in vitro and in vivo experimentation in murine, swine, and human of solid tumors. The Post Doc will have the opportunity to learn about writing and submitting their own independent federal grants (USA). Other responsibilities will include communicating results to the scientific community through publications and presentations, and supervising graduate students, clinical residents, and laboratory technicians. Weekly attendance and presentation of data at lab meeting is expected. Presentation of results for submission of manuscripts to international journals is expected for this position.
This position is funded by NIH grants.
Our ideal candidate will have:
- A Ph.D. in the field of chemistry, bioengineering, materials science, chemical engineering, biochemistry, biology or similar field;
- Prior research experience should include: organic chemistry, polymer chemistry, nanomaterials, or peptides-based agents
- Experience with standard characterization techniques required;
- Experience with manuscript writing, preparation of figures is required;
- Experience small animals (mice) is a benefit, but not required;
- Broad knowledge and experience in contrast agents and various imaging modalities is a strength;
- Must show technical proficiency and have the ability to collaborate within a multi-disciplinary group;
- Must have good record keeping skills;
- Must follow safety procedures and maintain a safe work environment;
- Strong interpersonal skills and the ability to contribute in a multidisciplinary team setting are mandatory.
Keywords: chemistry, organic chemistry, polymer chemistry, nanomaterials, nanoparticles, material science, contrast agent, imaging
The position is full-time for one year with the option to extend dependent on Post Doc performance and available funding. This project builds upon the work of Dr. Lacey McNally, an NIH funded investigator for the last 14 years. Salary will be based on experience and will use the NIH scale.
Interested candidates must apply online at https://jobs.ou.edu, job number 230418.
“The University of Oklahoma is an Equal Opportunity Institution. For more information go to www.ou.edu/eoo.”
3/8/2023
A postdoctoral fellowship is available in the laboratory of Dr. Jacob E (Jed) Friedman, new Director of the Harold Hamm Diabetes Center at the University of Oklahoma Health Sciences Center. A major leadership gift of $34 million has allowed for the expansion of laboratories and Endowed Chairs for research on developmental origins of disease (DoHAD). We are seeking highly motivated and independent postdoctoral fellows, with expertise in nutrition and the molecular or clinical aspects of obesity, diabetes or its complications, specifically in the liver, adipose biology, or innate immune system. Dr. Friedman’s research projects provide opportunities to have major, positive impacts on human medicine by investigating how maternal obesity impacts the development of establishment of the innate immune system (bone and liver) and development of obesity and non-alcoholic fatty liver disease in Mouse, Monkey and Man. The lab also has funded projects focusing on nutrition and microbiome development and biomarkers of disease in humans and mouse models.
Expertise in assessment of the effects of nutrition on the development of adipose, liver, immunity, or microbiome is desired. Responsibilities will include working with mice, routine cell culture, protein and RNA isolation from cells and tissue, Western blotting, and tools for investigating epigenetics or cell transcriptomics in bone-marrow and liver-derived cells. The ideal candidate will be reliable, personable, highly motivated, and have demonstrated the ability to work independently. This is an excellent opportunity to join a highly integrative, translational and productive research group, with high impact papers in top journals including PNAS, JCI, Nature Communications, and Cell Reports.
https://medicine.ouhsc.edu/Academic-Departments/Physiology/Faculty/jacob-e-jed-friedman-phd
Dr. Friedman’s lab has state-of-the-art equipment including a Cytation 5 multi-mode imager, a Jess Simple Western system, and a QuantStudio 6 real-time PCR machine. Campus shared resources and cores include: Tissue Banking and Pathology; Biostatistics and Research Design; Mass Spectrometry / Proteomics; DNA Sequencing / Genomics; Flow Cytometry / Imaging; Diabetic Phenotyping; Germ-Free Facility; Non-Human Primates, and Mobile Health (mHealth) Technology Network (NCTN), with robust pilot funding and training grants in diabetes, cancer, gerosciences, and developmental immunology.
Prerequisites:
- Graduation from an accredited college or university with a PhD in nutrition, physiology, immunology, molecular biology, biochemistry, cell biology, or closely related fields
- Minimum of 2-3 year(s) experience in working with in vivo models relevant to obesity.
- Excellent communication skills
- Proven ability to work independently within a research lab.
- Demonstrated proficiency in computer software (Microsoft Office, SAS), standard laboratory equipment operation, and research technical skills
Salary & Benefits:
Salary will be based on the NIH stipend scale and will be commensurate with skills and experience. The University of Oklahoma Health Sciences Center offers postdocs most employee benefits.
Applicant Instructions
- Applicants may apply directly to Dr. Jacob Friedman, Director Harold Hamm Diabetes Center at: jed-friedman@ouhsc.edu
- Required application materials:
- Cover letter
- Resume/Curriculum Vitae
- Contact information for a minimum of [3] professional work references
The University of Oklahoma medical campus is committed to providing a safe and productive learning and living community. To achieve that goal, we conduct background investigations for all final applicants being considered for employment. Background investigations include a criminal history record check, and when appropriate, a financial and/or motor vehicle history.
The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. The University of Oklahoma strongly supports the principle of diversity. The University of Oklahoma is an Equal Opportunity Institution. Protected veterans and individuals with disabilities are encouraged to apply.
Please be advised that the University does check references as part of the employment process, and selection committee members may choose to contact work references during the search process other than those listed in your application.
The University of Oklahoma is an Affirmative Action/Equal Opportunity Employer http://www.ou.edu/eoo/ . Protected veterans and individuals with disabilities are encouraged to apply.
Posted 12/7/2022
We are seeking a highly motivated and dedicated scientist with a deep understanding of immunology to join our team investigating mechanisms of radiation-induced immune and inflammatory responses. The candidate should be open to explore new opportunities and disciplines. The post-doctoral scientist will work at Oklahoma University in the department of Radiation Oncology.
The appointee will work on the elucidation of the mechanism of Radiation-induced immune suppression using a combination of immunology, molecular biology, and genetics/genomics approaches. The project will focus on T cell development, inflammation and immunity and would need knowledge in variety of immunological assays and biological systems. The project is translational and highly collaborative.
Prerequisites:
- A recent graduate with a PhD in Immunology or a related field
- A strong publication record
- Ability to design and conduct experiments independently
- Ability to work with others as a team
- Required to read new publications and write manuscripts and fellowship applications.
- Present their research at national and international meetings.
- Excellent command of the English language.
- Experience with mouse models and cellular immunology.
Preferred:
- Radiation biology or stem cell biology
- Experience with advanced molecular biology or biochemical techniques such as single cell RNA seq, CRISPR-Cas9 technology, genomics and/or proteomics.
While funding will be provided for this position, the appointee will be encouraged to write and apply for outside funding in order to help career development.
Interested applicants should send a cover letter highlighting prior experience and CV to
dinesh-thotala@ouhsc.edu
Posted 10/27/22
A postdoctoral position is available at the University of Oklahoma Health Sciences Center in Dr. Mary Beth Humphrey’s lab to study molecular mechanisms of mesenchymal stem cell regulation and the role of vagal nerve stimulation in prevent pain and joint destruction in mouse models of osteoarthritis.
Candidate should have a Ph.D. with experience in bone biology, immunology, molecular biology, cell biology, or biochemistry. Experience with mammalian cell culture, recombinant DNA technology, cellular signaling and mouse models of bone disease are preferred. Candidate must be able to plan and perform experiments in an independent manner with appropriate supervision, have excellent communication skills and strong interpersonal skills. Candidate will also be responsible for writing papers, protocols and lab reports associated with this project. Highly motivated individuals who wish to develop careers as independent scientists are encouraged to apply. Preference will be given to candidates with documented success in research, such as recent first author publications and aspirations for an independent scientific career. Please provide your CV, letter of interest, and contact information for 3 references, including current employer by email.
Contact via e-mail to marybeth-humphrey@ouhsc.edu.
Posted 9/28/22
A position for a post-doctoral fellow is available in the laboratory of Dr. Carol Webb in the Department of Medicine, Division of Rheumatology, Immunology and Allergy at the University of Oklahoma Health Sciences Center in Oklahoma City. We are seeking a highly motivated person with an outstanding work ethic. Funded projects seek to determine mechanisms for autoimmune activation in human blood cells and for development of kidney organoid cultures from adult stem cells. Prior experience with tissue culture, flow cytometry and molecular biology would be beneficial. Successful candidates will have strong oral and written communication and organization skills. The environment at OUHSC is diverse and inclusive.
To apply, email a cover letter describing research interests, a CV and names and contact information of three references directly to Dr. Webb at carol-webb@ouhsc.edu.
Posted 9/22/22
The Hannafon Laboratory at the University of Oklahoma Health Sciences Center is seeking a postdoctoral fellow to study drug development and anti-tumor targeting mechanisms of a novel therapeutic combination in breast cancer. The successful candidate should be a highly ambitious and self-motivated scientist with good organization skills, and excellent written and verbal communication skills.
The research focus of the Hannafon laboratory is to discover and investigate the molecular mechanisms of breast and gynecologic cancer development, progression, therapeutic response, and resistance. We are especially interested in the role of small extracellular vesicles, known as exosomes, in intercellular communication in the tumor microenvironment, and evaluate their use as biomarkers. An additional focus of the laboratory is anti-cancer drug development for improved targeting and therapeutic response in gynecologic and breast cancers.
Interested candidates should send a CV, a brief one-paragraph description of previous research experience, and a list of 3 references to Bethany-hannafon@ouhsc.edu
Requirements
Teamwork: Being a good laboratory member and working collaboratively with others.
Cell culture. Maintain cell cultures and reagents, and cell line inventories. Conduct experiments to analyze the effects of treatments using various assays.
Animal Testing. Must Perform specialized tests on experimental animals including tumor cell injection, weighing, administration of drugs, maintaining a census, and surgeries in mice models.
Molecular, Cellular, and Biochemical Analysis. Perform a variety of assays on cell cultures, and human or animal tissues, including DNA/RNA/protein extraction, PCR, growth assays, immunoblotting, and other specific routine assays, as required.
Data Collection and Maintenance. Enter, compile and graph data, maintain a laboratory notebook, and file reports. May perform data analysis.
Equipment Maintenance. Maintain laboratory space, laboratory supplies, and equipment, assesses lab group needs to order and stock supplies and equipment.
And as Needed. Perform various duties as needed to successfully fulfill the function of the position.
Duties
The candidate will be expected to perform research, write manuscripts, and present findings at local and national meetings. The candidate will also assist in writing grant proposals and will be highly encouraged to submit fellowship applications (both intramural and extramural).
Preferred
Previous experience in Animal handling and willingness to work with mice.
Application
Please submit the following documents to Bethany-hannafon@ouhsc.edu
- CV
- One paragraph description of previous research experience
- List of 3 professional references.
Remains valid as of 9/5/22
A postdoctoral position at the Stephenson Cancer Center, University of Oklahoma Health Sciences Center (OUHSC) in Oklahoma City, Oklahoma, is immediately available to study chronic lymphocytic leukemia (CLL) biology and signaling involving crosstalk of the malignant cells with the CLL tumor microenvironment.
A highly motivated scientist with a fresh PhD is encouraged to apply. Candidates with experience in cancer biology, molecular biology, and animal models (xenograft as well as transgenic) are preferred. The candidate should have first-hand experience in routine laboratory techniques including but not limited to cell culture, western blots, immunoprecipitation, apoptosis assays, confocal microscopy, PCR/qRT-PCR and other related biochemical assays. Experience in flow cytometry will be an added qualification.
To apply, please send a cover letter stating your research interests and experience along with a curriculum vitae and three references to asish-ghosh@ouhsc.edu.
The Stephenson Cancer Center is an NCI-designated cancer center with interacting teams of scientists supported by an array of core facilities and located on a large OUHSC research campus. OUHSC is one of only four comprehensive academic health centers in the nation with seven health professional schools, providing a broad base of expertise for comprehensive clinical and basic science research, interdisciplinary interaction, and career development. Oklahoma City is a large metropolis with western charm, easy local transportation, vibrant downtown, and excellent suburbs.
The University of Oklahoma Health Sciences Center is an Equal Opportunity/Affirmative Action employer that is strongly and actively committed to diversity within its community. All qualified applicants will receive equal consideration for employment without regard to race, color, religion, political beliefs, national origin, age (40 or older), sex (see: Sexual Misconduct, Discrimination policy) sexual orientation, genetic information, gender identity, gender expression, disability, or veteran status.
Posted: 7/6/22
A lab in University of Oklahoma Health Sciences Center (OUHSC) has an open position for a postdoctoral fellowship in cardiovascular drug development. Applicants with a strong background in cardiovascular research, including rodent model development, cell culture, advanced biochemical techniques, HPLC, etc. are especially encouraged. The successful candidate will be part of a dynamic lab with synergistic skills and experiences and will be given the opportunity to develop new projects that complement the overall directions of the lab. This is a mentored position where incumbents plan, design and conduct research experiments, manage research projects, prepare reports and papers for publication, presentation and future research. The fellow will actively contribute to grant writing and will be encouraged to write applications for independent fellowships. An ideal candidate will have Ph.D. in a biological science, chemistry, or other relevant area, or M.D., or equivalent. History of work in myocardial infarction and/or stroke mouse models preferred. Publication of at least 2-3 peer-reviewed articles is expected. Experience planning and effectively executing animal projects and maintaining animal colonies, surgical techniques, Western blotting, RT-PCR, Flow cytometry and other advanced molecular techniques. Must have the ability to multitask and work both independently and as a member of an interdisciplinary team with attention to detail.
Benchmark Expectations
- · Conduct scientific research.
- · Manage research projects and maintain documentation.
- · Present scientific information both formally and informally.
- · Prepare papers for publication and contribute to grant writing.
- · Perform lab management responsibilities as assigned.
- · Work collaboratively and collegially as part of the team while developing skills needed as an independent scientist.
- · Have experience and/or exposure to cardiovascular or a closely related field.
To apply, please send your current cv and a list of three references (email and phone number) to vawasthi@ouhsc.edu.
Posted 10/04/2021
The incumbent will perform research using microbiological, molecular and cellular techniques as well as collaborating with others to perform neuro-cognitive assessments to neuroinflammation and its effects on cognitive function, particularly in the context of aging. Full job description is here.
Inquiries and Applications: Dr Doug Drevets Douglas-Drevets@ouhsc.edu with a cc to Wendy Newport, Section Manager.
Posted 9/10/21 (Remains active as of 9/1/22)
A postdoctoral position is available immediately in the Department of Biochemistry and Molecular Biology and the Center for Geroscience and Healthy Brain Aging at the University of Oklahoma Health Sciences Center. The applicant will work on mechanisms of pathogenesis of Alzheimer’s disease (AD) and related dementias using rodent models, with a specific focus on the role of mechanisms of aging, pathogenic tau, and cerebrovascular pathways of AD. For more information please see the laboratory’s website https://www.galvanlab.org.
The successful candidate should hold a Ph.D. in neuroscience, biochemistry, genetics, cellular or molecular biology, physiology, or other related fields and have a record of creativity and strong scientific productivity. Working experience on mouse models, assessment of brain vascular function, optical imaging, primary neuron cell culture, molecular biology and mouse genetics, and a background in neuroscience and brain vascular biology are strongly preferred, but not exclusively required. Please provide a curriculum vitae, a brief summary of research experience and goals, and the names and contact information of three references to Dr. Veronica Galvan (galvanv@uthscsa.edu) or to Dr. William Sonntag (william-sonntag@ouhsc.edu) on behalf of Dr. Veronica Galvan.
Posted: June 23, 2021
The Benbrook Research Group at the University of Oklahoma Health Sciences Center is recruiting a post-doctoral fellow who is collaborative and interested in researching anti-cancer drug development against Gynecological Cancers. Interested candidates should send a CV, a brief one paragraph description of previous research experience, and a list of 3 references to Doris-Benbrook@ouhsc.edu; Vishal-Chandra@ouhsc.edu; Rajani-Rai@ouhsc.edu
Requirements:
Cell culture. Maintain cell cultures and reagents, cell line inventories and conduct experiments to analyze effects of treatments using various assays. Animal Testing. Must Perform specialized tests on experimental animals including tumor cell injection, weighing, administration of drugs, maintaining a census, and surgeries in rat or mice models. Molecular, Cellular and Biochemical Analysis. Perform a variety of assays on cell cultures, and human or animal tissues, including DNA/RNA/protein extraction, PCR, growth assays, immunoblotting, and other specific routine assays, as required. Data Collection and Maintenance. Enter, compile and graph data, maintain laboratory notebook and file reports. May perform data analysis. Equipment Maintenance. Maintain laboratory space, laboratory supplies and equipment, assesses lab group needs to order and stock supplies and equipment. And as Needed. Perform various duties as needed to successfully fulfill the function of the position.
Duties:
Candidate will be expected to perform research, write manuscripts, and present findings at local and national meetings. Candidate will also assist in writing grant proposals and will be highly encouraged to submit fellowship applications (both intramural and extramural).
Preferred:
- Previous experience in Animal handling and willing to work with rats, mice.
Application:
Posted: June 18, 2021 (Remains active as of 9/1/22)
The Harold Hamm Diabetes Center (HHDC) at the University of Oklahoma (OU) invites applications for a postdoctoral research associate position in computational biology and bioinformatics. HHDC has an exceptional and expanding research program focusing on the early origins of diabetes and obesity in children. The candidate will be co-mentored by HHDC Member, Dr. Chongle Pan, and HHDC Director, Dr. Jacob E. Friedman. Dr. Pan is an Associate Professor in the School of Computer Science and the Department of Microbiology and Plant Biology in OU Norman. Dr. Friedman is a Professor of Physiology, Biochemistry & Molecular Biology, and Pediatrics & Medicine at OU Health Sciences Center.
They have formed an active ongoing collaboration and partnership for tools ranging from transcriptomics, metabolomics, epigenetics, to metagenomics of the microbiome.
https://medicine.ouhsc.edu/Academic-Departments/Physiology/Faculty/jacob-e-jed-friedman-phd
http://www.ou.edu/coe/cs/people/pan
http://www.ou.edu/cas/mpbio/people/faculty/pan
The research will focus on the characterization of risk factors for diabetes in early childhood. The risk factors will include childhood microbiota dysbiosis, genetic predisposition, and maternal metabolism disorders. Key molecular determinants for these risk factors will be identified from multi-omics data, which will be used to develop testable hypotheses for follow-on molecular biology experiments and build computational models for predicting and understanding diabetes.
Job Responsibilities:
The candidate is responsible for analyzing and mining multi-omics data using computational techniques, such as machine learning, generalized linear mixed models, and biological network analysis. This may require development of new computer algorithms and/or construction of computational workflows on computer clusters. The types of multi-omics data will include longitudinal metagenomics sequencing data, genome-wide association (GWAS) data, proteomics data, and metabolomics data. The candidate is expected to publish their findings in peer-reviewed journals.
Qualifications:
- Ph.D. in bioinformatics, computer science, or a related field.
- Strong publication track record
- Relevant prior research experience
Application Instructions:
Applicants should submit CV and cover letter in electronic format (only) to Patricia-Parker@ouhsc.edu
Questions about the position may be directed to Dr. Chongle Pan at cpan@ou.edu or Dr. Jacob Friedman at jed-friedman@ouhsc.edu
The University of Oklahoma is an Affirmative Action/Equal Opportunity Employer http://www.ou.edu/eoo/ . Protected veterans and individuals with disabilities are encouraged to apply.
Posted 12/7/2022